Immunity
The Nutrire Program is designed to provide safe and natural solutions to the challenges faced in animal production, composed by lines:
Innovations in
Feed Efficiency
Innovations in
Toxin Removal
Innovations in
Functional Ingredients
Innovations in
Piglet and Pet Nutrition
Innovations in Feed Efficiency
During the evolution process of certain plant species, secondary compounds were formed and selected as plants’ protection agents against the attack of bacteria, viruses and fungi. These simple molecules possess different mechanisms of action, which is a fundamental fact explaining why these metabolites are unable to generate microbial resistance.
For thousands of years human kind has explored the antibacterial, antifungal, anti-inflammatory and olfactory properties of essential oils. In recent decades, science has devoted studying the application of these substances in animal nutrition. GRASP offers products based on essential oils, aiming to increase animal productivity.
Besides its nutraceutical properties, the utilization of these natural raw materials is a strategy to reduce the antibiotics use in animal husbandry, especially as they do not create microbial resistance and they are also recognized as “GRAS” (Generally Recognized as Safe) substances by agencies such as the FDA (Code of Federal Regulations, title 21, part 582) and the Council of the European Union (Directive 70/524/EEC Chapter III).
Innovations in Piglet and Pet Nutrition
A line of products based on hyper immunized egg immunoglobulins (IgY), developed by the world’s Immunoglobulins’ research and application leader – Immunology Research Institute in Japan. Immunoglobulins are used in critical rearing phases of piglets and calves as well as for oral and intestinal prevention in dogs and cats.
Immunoglobulins or “Ig” are naturally found in all animals and represent the major class of antibody. They are macromolecule proteins, which are able to bind to pathogens, being so responsible for defending the body.
Young animals are vulnerable during their first weeks of life. While their immune system is not yet fully developed, there is a rapid decrease of the maternal immune defense (via colostrum). Challenges such as pathogens in the environment and stress by changes in management and nutrition contribute and have a negative impact on the animal, resulting in poor performance.
Extensive scientific studies, carried out in close cooperation with independent universities and other scientific institutions, demonstrated the positive benefits of our products.
Innovations in Toxin Removal
There are several bacterial-derived bioactive substances that cause enteric diseases, triggering immune and proinflammatory reactions in animals. Among the main infectious agents, we can point out E. coli and Clostridium sp.
• Exotoxins are proteins actively secreted by Gram-positive and Gram-negative bacteria during their growth.
• Endotoxins are lipopolysaccharides (LPS), which are constituents of the outer membrane of Gram-negative bacteria, being released during bacterial growth or cellular lysis.
Aerobic fungi, especially from the genera Fusarium sp. and Aspergillus sp., produce metabolic toxins, which are present in grains, by products and conserved forages (hay and silage) offered to livestock. Their main effects in animals are the reduced feed intake, performance, immunity and fertility, as well as higher incidence of reproductive disorders.
“Around 400 different mycotoxins are known, of which the most harmful are Aflatoxin, Fumonisin, Zearalenone, T2 toxin, and DON, which can act individually or synergistically leveraging its negative effects on the animal.”
Mixing adsorbents in feed is the most suitable form of prevention, because they chemically bind to toxins in the gastrointestinal tract, decreasing their bioavailability and toxicity.
The choice of adsorbent should ideally take into account:
And all these results must be confirmed by laboratory reports (IN13).
Functional
Ingredients
Prebiotics are non-digestible carbohydrates and non-absorbable in the upper gastrointestinal tract (GIT).
They stimulate the growth of beneficial intestinal microflora such as Bifidobacterium sp. and Lactobacillus sp. These bacteria consequently increase the production of lactic acid and acetic acid, thereby decreasing the development of enterobacteria.
In addition, the β-glucans and mannanoligosaccharides present in prebiotics attach to the bacteria carrying type I fimbriae, such as Salmonella sp. and Escherichia coli, agglutinating them and allowing their elimination through feces. The increase in the ratio between beneficial bacteria and pathogens improves performance parameters, including for instance feed conversion.